Nokia & Microsoft Alliance Essay Example for Free

Nokia Microsoft Alliance Essay Microsoft would in turn provide support to Nokia in selling its new Windows Phone powered smartphones. Nokia’s Canadian CEO, Stephen Elop, and Steve Ballmer, his Microsoft counterpart, announced that Nokia would make Windows Phone its main phone platform, a move that effectively confirms that Nokia’s own platforms, Symbian and MeeGo, were uncompetitive and they would be tossed onto the technology scrap heap. There were mixed reactions from analysts to the alliance between Nokia and Microsoft. The challenge before the senior management at Nokia and Microsoft was how to make the alliance work. Nokia once dominated the market for standard â€Å"feature phones† and smartphones, the Internetenabled, multi-media devices that are becoming must-have tools for the business and high-end consumer markets. But Nokia’s Symbian OS has not proved popular with consumers, who have been migrating en masse to Android and Apple phones. As a result, Nokia began to face severe competition from companies like Google, Inc. and Apple, Inc. ho entered the market for high-end smartphones after 2007. Analysts said Nokia’s poor focus on software and the lack of the latest OS on its smartphones were the main reasons for its declining market share in the last years. In the autumn of 2010, Nokia faced three choice: the first was to keep developing its own OS, Symbian and MeeGo; the second was to adopt Google’s Android system; and the third was to go with Microsoft. The first option was dropped because of the long lead times that would be required to update Symbian and get M eeGo launched. Android dropped off the list because of the difficulties they were facing in â€Å"differentiating [ourselves] in that ecosystem †¦ [Going with Google] would have felt a bit like giving up†. In the smartphone industry, an ecosystem is the association of hardware developers (in this case Nokia), software developers and the builders of applications, ecommerce, advertising, social applications, multimedia services and the like. The last option – the partnership with Microsoft – was considered the best option. As a result, in September 2010 Nokia’s board appointed a new CEO, Stephen Elop, who was a former executive at Microsoft, to bring more of a focus on software and put the basis of NokiaMicrosoft partnership. Referring to this partnership and the attempt to prevent Google’s Android 1 OS and the Apple’s iPhone from owning the entire smartphone market, Mr. Elop said that â€Å"this is now a three-horse race†. Seated next to Mr. Elop in a London hotel auditorium, Mr. Ballmer said â€Å"this partnership with Nokia will accelerate – dramatically accelerate – our Windows phone ecosystem†. However, the partnership did not impress investors, who drove down Nokia’s shares in Europe at the beginning of February 2011. Analysts said the plunge was in good part due to Nokia’s warning of â€Å"significant uncertainties† over how the changes would affect the Finish company’s performance. Soon after taking over as CEO of Nokia, Elop sent out a memo to the employees emphasizing the need to bring about drastic changes at the company. On the other hand, Mr. Elop said the partnership with Microsoft was only part of Nokia’s strategy to recapture market share and improve profitability in a viciously competitive market, meanwhile extensive firings at both the senior management and factory level were expected in various parts of the world, including Finland. In a Reuters report, Finland’s Economy Minister Mauri Pekkarinen said that Nokia’s restructuring after the partnership with Microsoft â€Å"is the biggest structural reform which has ever impacted new technology in Finland†. As a result of the partnership agreement, Nokia’s hefty research and development budget would also come down. The partnership with Microsoft will see the fledgling Windows Phone 7 platform become the dominant platform on Nokia phones. This means that Nokia will eventually cease shipping phones equipped with its workhorse Symbian system, though the company still expected to sell another 150-million products in 2011. Microsoft Phone 7 was launched in 2010 and the first phones with the OS arrived on the market in October 2010; still, the system’s market share is tiny – no more than 3 per cent.

Toxic Effects of Aluminum and Their Probable Association with Dialysis

Toxic Effects of Aluminum and Their Probable Association with Dialysis Encephalopathy Reports on the neurotoxic properties of Aluminum (Al++), as well as those of many other heavy metals, date as far back as the end of the nineteenth century. In 1965, Al was found to induce the formation of neurofibrillary tangles (NFT) in animal brains. These NFT’s were similar to those found in brains of patients suffering from Alzheimer’s Disease (AD). Vast research thus, was targeted at defining the possible etiologic role of Al in AD. However, several findings, among them the fact that Al++ induced NFT’s are structurally different than those found in AD, have contributed to reducing the importance placed on Al++ as an etiologic factor of AD. The Al++ theory, however, still remains a theory, and further research needs to be done before it can be disproved. In 1970, Alfrey and collaborators described a disease called dialysis encephalopathy (DE). This degenerative disease was seen in renal failure patients who had been undergoing dialysis. Studies following this initial report have implicated Al++ intoxication as a probable cause for the development of the disease. The purpose of this paper will be to describe the possible mechanisms by which Al may in fact act as a contributory factor the in induction of neural degeneration that may lead to DE. The neurological problems associated with chronic renal failure and its consequent treatment, namely hemodialysis, can be either acute or chronic. When acute, the patient develops a set of symptoms collectively referred to as dialysis disequilibrium syndrome (DDS). This syndrome presents with a transient loss or alteration of the sense of equilibrium due to disturbances to the vestibular sy... ...on, G., Cogdill, K., Jope, R. Oral Aluminum Alters In Vitro Protein Phosphorylation and Kinase Activities in Rat Brain. Neurobiology of Aging, 11: 209-16 (1990). 5) Johnson, G., Li, X., Jope, R. Aluminum Increases Agonist Stimulated Cyclic AMP Production in Rat Cerebral Cortical Slices. Journal of Neurochemistry, 53: 258-63 (1989). 6) Kerr, D., Ward, M., Ellis, H., Simpson, W. Aluminum Intoxication in Renal Disease. CIBA-Found-Symposium, 169: 123-41 (1992). 7) Langui, D., Probst, A., Anderton, B. Aluminum Induced Tangles in Cultured Rat Neurons. Acta Neuropathol., 80: 649-55 (1990). 8) Meiri, H., Banin, E., Roll, M., Rousseau, A. Toxic Effects of Aluminum on Nerve Cells and Synaptic Transmission. Progress in Neurobiology, 40: 89-121 (1993). 9) Wisniewski, H., Wen, G. Aluminum and Alzheimer’s Disease. CIBA-Found-Symposium, 169: 142-64 (1992). Toxic Effects of Aluminum and Their Probable Association with Dialysis Toxic Effects of Aluminum and Their Probable Association with Dialysis Encephalopathy Reports on the neurotoxic properties of Aluminum (Al++), as well as those of many other heavy metals, date as far back as the end of the nineteenth century. In 1965, Al was found to induce the formation of neurofibrillary tangles (NFT) in animal brains. These NFT’s were similar to those found in brains of patients suffering from Alzheimer’s Disease (AD). Vast research thus, was targeted at defining the possible etiologic role of Al in AD. However, several findings, among them the fact that Al++ induced NFT’s are structurally different than those found in AD, have contributed to reducing the importance placed on Al++ as an etiologic factor of AD. The Al++ theory, however, still remains a theory, and further research needs to be done before it can be disproved. In 1970, Alfrey and collaborators described a disease called dialysis encephalopathy (DE). This degenerative disease was seen in renal failure patients who had been undergoing dialysis. Studies following this initial report have implicated Al++ intoxication as a probable cause for the development of the disease. The purpose of this paper will be to describe the possible mechanisms by which Al may in fact act as a contributory factor the in induction of neural degeneration that may lead to DE. The neurological problems associated with chronic renal failure and its consequent treatment, namely hemodialysis, can be either acute or chronic. When acute, the patient develops a set of symptoms collectively referred to as dialysis disequilibrium syndrome (DDS). This syndrome presents with a transient loss or alteration of the sense of equilibrium due to disturbances to the vestibular sy... ...on, G., Cogdill, K., Jope, R. Oral Aluminum Alters In Vitro Protein Phosphorylation and Kinase Activities in Rat Brain. Neurobiology of Aging, 11: 209-16 (1990). 5) Johnson, G., Li, X., Jope, R. Aluminum Increases Agonist Stimulated Cyclic AMP Production in Rat Cerebral Cortical Slices. Journal of Neurochemistry, 53: 258-63 (1989). 6) Kerr, D., Ward, M., Ellis, H., Simpson, W. Aluminum Intoxication in Renal Disease. CIBA-Found-Symposium, 169: 123-41 (1992). 7) Langui, D., Probst, A., Anderton, B. Aluminum Induced Tangles in Cultured Rat Neurons. Acta Neuropathol., 80: 649-55 (1990). 8) Meiri, H., Banin, E., Roll, M., Rousseau, A. Toxic Effects of Aluminum on Nerve Cells and Synaptic Transmission. Progress in Neurobiology, 40: 89-121 (1993). 9) Wisniewski, H., Wen, G. Aluminum and Alzheimer’s Disease. CIBA-Found-Symposium, 169: 142-64 (1992).

Human Rights and Social Skills Essay

Chairperson adjudicators, ladies and Gentlemen, welcome. The motion before the house this evening is that the internet does more harm than good, as a social media using teenager, the stereotypical opinion I would have on this matter would be that this statement is false, however ladies and gentleman, I am not a stereotypical teenager and I am of the opinion that the internet does indeed do more harm than good. The year is 2014, and the internet has seemingly taken over the world, the majority of the population of the world would claim that they wouldn’t be able to survive without the internet; in their eyes the internet can do no wrong. Ladies and gentlemen I’m afraid to inform you that they couldn’t be more delusional. In today’s society social skills are cast aside, and the internet is the main priority for most people. In my school for example at break times, the dining hall is as quite as funeral with young people’s heads stuck in iPhone and com puters. The sound of a good conversation is seldom found. Sadly ladies and gentlemen, this is the effect that the internet has had on our generation. I worry for some of my class mates when they decide to go to a job interview, they will stand no chance as the internet has deprived them of essential social skills required to succeed in the workplace, and in life. Secondly, in life we are blessed with certain rights, the right to water and the right to free speech and so on. But there is one right that he internet has clinched away from us, and this is the right of privacy. You don’t have to look back decades to see an incident of personal invasion through the internet. Just this year numerous celebrities computers were hacked and personal pictures and information was stolen. It sickens me to think we live in a world where we can’t have privacy. Internet hackings have sadly become all too common on the news and in the public domain. Banking for example, was once considered a safe and innocent act. Alas, its reputation has been tarnished by internet hackers. I myself have been affect by this as my own personal bank account has been hacked. I have never used the internet in the same way after that incident. It might seem farfetched ladies and gentlemen, and you might feel safe, but I warn you, the internet is not a safe place, and in my opinion it has done more harm than good to the lives of innocent people. Lastly, the internet hasn’t just harmed the lives of my age group; oh no it has negative effects on much more age categories as well. For example the  elderly and the very young. These groups of people are being all too easily led into a false sense of hope by internet scams. Deals on life assurance, fun seemingly ‘free’ online games are just some of the many examples of how the internet exploits these people. Too many countless innocent people have been left out of pocket after falling f or these internet scams. My mind is cast back to last year when a child in Dublin spent 347 euro on in- game purchases on the popular internet game candy crush. Unknowing to the child she consistently purchased in game accessories and bonuses to the total of 347 euros. I’d say her father was none too pleased and wanted to crush something other than candy! This is just one of thousands of examples of how people are exploited on the internet every day, thus proving that it does more harm than good. Alas ladies and gentlemen, I believe there is hope, if better safety sanctions and regulations are used I do believe the internet can become a helpful and beneficial resource for everyone to use. But until that day comes, I am positive that the internet does cause more harm than good . Thank you.

A Study On Breast Cancer - 843 Words

Breast Cancer Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women (Up to Date, 2014). The associated risk can be as high as 12% for every woman in the United States, regardless of family history (American Cancer Society, 2013). For this reason, care begins with patient education, risk stratification, and preventative medicine. The paper will review preventative options, risk stratification based on genetics and age, and breast cancer treatment. Preventative Options Prevention of breast cancer begins with education of evidence-based preventative strategies. Modifiable risk factors such as the maintenance of a healthy weight and a diet rich in cruciferous vegetables, beta-carotene, fruits, fiber, whole grains, can lower the risk of breast cancer by 13% (Marshall, 2013). Moreover, omega-3 fatty acids, soy products, and curcumin have demonstrated some reductions in risk related to the protective pathophysiology. In addition, avoidance of alcohol can lessen the risk (Zhang, Simondsen, Kolesar, 2012). As a result, when women practice these preventive lifestyle modifications, breast cancer can be â€Å"minimally reduced by 38%† (American Institute of Cancer Research, 2014). Additionally, the integration of a detection plan is essential to identify disease early. Beginning at age forty, a yearly mammogram can help to recognize cancer in the early development (American Institute of Cancer Research, 2014). According to theShow MoreRelatedA Study On Breast Cancer2075 Words   |  9 PagesBreast cancer is a disease that starts when an abnormal, uncontrolled cell growth occurs in the tissues of the breast. In a healthy body, cells grow, divide, and die in an orderly way, but once a damage or a mutation happens in the genetic material of the cell (which is found in the DNA) it results in cells that do not die. They continue to grow and divide uncontrollably and form abnormal cells that the body does not need. They can also metastasize, which means they invade other tissues through theRead MoreA Research Study On Breast Cancer1308 Words   |  6 PagesIntroduction Breast Cancer is on the fore-front of modern tumor research and scientists are continually seeking for new ways to treat and prevent cancer progression. Current treatments by hormone-dependent drugs like Tamoxifen and Raloxifene focus on estrogen receptor inhibition in mammary and endometrial cell lines. This group of drugs are known as selective-estrogen receptor modulators or SERMS, which are effective in estrogen-receptor positive (ER+) and hormone-estrogen receptor 2 positiveRead MoreBreast Cancer Case Study1306 Words   |  6 Pagesmetastases have caused substantial mortality and morbidity in cancer patients. Approximately 15% of women with breast cancer will be diagnosed with brain metastases (Zakaria et al., 2014). With early diagnosis and appropriate treatment, the quality of the patient’s life could be enhanced. Therefore, it is vital for patients with a known primary tumour to undergo imaging studies once they develop neurological signs and symptoms. Imaging studies aid to accurately identify the type, number, size, and locationRead MoreA Research Study On Breast Cancer1702 Words   |  7 PagesIntroduction Breast cancer is one of the leading causes of high mortality and morbidity in women population worldwide. Up to date, no effective breast cancer treatment has been developed and this has motivated academic scientists for the quest for alternative drugs and the discovery of drug targets. Increasing evidence suggests that carotenoids, which are micronutrients in fruit and vegetables, reduce breast cancer risk [1]. Previous findings suggest a protective role of ÃŽ ±-carotene, ÃŽ ²-carotene,Read MoreBreast Cancer Case Study929 Words   |  4 PagesIn the present study, we found that rate of pCR to neoadjuvant chemotherapy was 24.7% (n=25) in the whole cohort (n=101). This finding was consistent with the range of pCR rates to prospective randomized trials of preoperative chemotherapy of 15%-40% mentioned in the literature (Burstein et al., 2008). Moreover, high Ki-67 expression (cutoff 14%) was significantly correlated with achieving a pCR in the large cohort (p=0.016). This result matched with the finding of several studies that reported thatRead MoreA Research Study On Breast Cancer2138 Words   |  9 Pages Breast Cancer accounts for more than 20 percent of cancer in women, and is the primary cause of cancer death among women globally.1 Despite extensive scientific research on the disease, the outlook on a cure arguably remains poor. While some breast cancer survivors and women at high risk remain hopeful that soy intake will reduce the risk or even cure cancer, the recommendations are conflicting. For decades, the relationship between soy foods, supplements, phytoestrogen intake and cancer hasRead MoreBreast Cancer Case Study1234 Words   |  5 Pagesultimately lead to the progression of oral cancer. (Lee et al, 2010). c‑myc was among the first oncogenes found to be amplified in breast cancer, and it can contribute to many other forms of cancer (Victoria and Michael, 2007). It is a critical downstream effector of the Wnt/TCF pathway in colon cancer and activation of Myc might play a predominant role in the pathogenesis of tumors like pediatric hepatoblastoma (Sansom et al, 20 07; Cairo et al, 2008). A study done in south Indian population has shownRead MoreBreast Cancer Case Study803 Words   |  4 Pagessecondary organs fibronectin expression is upregulated by primary tumors via resident fibroblasts, which serves as a docking site for VEGFR1+ hematopoietic progenitor cell (HPC) clusters and secondary seeding. During metastasis of breast cancer to lung, interaction of VCAM-1+ cancer cells with VLA-4-expressing macrophages, activates PI3K/Akt signaling in tumor cells, protecting them from caspase-induced apoptosis. Bone metastasis is also facilitated by interaction of VCAM1 with different integrin partnerRead MoreA Research Study On Breast Cancer981 Words   |  4 PagesIn this case study we have Sarah a forty-two-year-old woman who has breast cancer which has metastasized to her lungs. Despite having had multiple tumors removed the cancer has returned. Sarah’s oncologist, Greg, recommends that she take part in a double blind experimental drug trial in an effort to slow the occurrence of more tumors. Greg explains that the risks of the drug are not entirely known; the drug won’t cure her cancer but may slow its progression, it may leave her extremely fatiguedRead MoreStudy On Breast Cancer Management Guidelines Essay1584 Words   |  7 Pages STUDY ON BREAST CANCER MANAGEMENT GUIDELINES ABSTRACT- Cancer is a big cause of death worldwide. Around the world Cancer of different types effect millions of population and leads to loss of lives. According to the available data through our complete and thorough nationwide registries on cancer (number of times something happens), number and death in India among males cancers of lung, mouth, oesophagus and stomach are leading places/locations of cancer and among females cancer of breast, cervix